The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements

@inproceedings{Cass2011TheFZ,
  title={The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements},
  author={Danielle M Cass and Rachel Hotchko and Paul Barber and Kimberly A Jones and Devika P. Gates and J Andrew Berglund},
  booktitle={BMC Molecular Biology},
  year={2011}
}
Muscleblind-like 1 (MBNL1) is an alternative splicing factor containing four CCCH Zinc fingers (ZnFs). The sequestration of MBNL1 by expanded CUG and CCUG repeats is a major component in causing myotonic dystrophy. In addition to binding the structured expanded CUG and CCUG repeats; previous results suggested that MBNL1 binds single-stranded RNAs containing GC dinucleotides. We performed a systematic analysis of MBNL1 binding to single-stranded RNAs. These studies revealed that a single GC… CONTINUE READING
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