The foundation of two distinct cell lineages within the mouse morula

@article{Johnson1981TheFO,
  title={The foundation of two distinct cell lineages within the mouse morula},
  author={Martin H. Johnson and Carol Ann Ziomek},
  journal={Cell},
  year={1981},
  volume={24},
  pages={71-80}
}

Properties of polar and apolar cells from the 16-cell mouse morula

TLDR
The surface properties of newly formed, isolated 1/16 mouse blastomeres have been analyzed over the 10–12 h period prior to their division to 2/32 cells and the results are discussed in the context of the normal fate and potential of each cell type within the morula.

The influence of cell contact on the division of mouse 8-cell blastomeres.

TLDR
It is suggested that cell interactions immediately prior to and during division do not influence strongly the orientation and position of the division plane, and interactions between the cells within an intact early 8-cell embryo do influence the type of progeny generated at division to the 16-cell stage.

Oriented cell divisions asymmetrically segregate aPKC and generate cell fate diversity in the early Xenopus embryo

TLDR
It is shown that oriented cell divisions generate the superficial and deep cells and establish cell fate diversity between them in Xenopus and only the progeny of the cells that inherit the apical membrane turn on the bHLH gene, ESR6e.

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

TLDR
A model in which the timing of cell internalization, cell position, and cell sorting combine to determine distinct lineages of the preimplantation mouse embryo is proposed.

Cytocortical organization during natural and prolonged mitosis of mouse 8-cell blastomeres.

TLDR
In mitotic cells at all stages from early metaphase to immediately postcytokinesis microvilli were found to be present over more of the cell surface, suggesting a heterogeneity of cytocortical organization may still exist within the arrested mitotic cell.

The developmental potential of mouse 16-cell blastomeres.

TLDR
Postimplantation development of blastocysts derived from aggregates of outer or inner cells, after transfer to pseudopregnant recipients, was normal and comparable to zona-intact control embryos.

Cell Polarity in the Preimplantation Mouse Embryo

TLDR
Attempts to elucidate the mechanisms by which these two distinct cell types diverge from a common pathway during the first 3 days of preimplantation development have yielded not only clues as to possible differentiative signals operating in development, but also detailed structural information on the morphology and properties of cells from the early embryo.
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References

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TLDR
When late 8-cell embryos were disaggregated to single cells, and these sorted by pattern of fluorescent-ligand binding, each of the four patterns of staining related consistently to a characteristic distribution of microvilli as viewed by scanning electron microscopy.

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TLDR
Investigations by Seidel and Tarkowski have shown that although the majority of 1/2 blastomeres can regulate and develop into smaller but otherwise normal blastocysts, som e of them give rise to purely trophoblastic vesicles devoid of the inner cell mass.

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TLDR
Results are reported, obtained by injecting donor cells into host blastocysts, showing that totipotent cells exposed only to blastocoele fluid differentiate into morphologically normal blastocyts, whereas those in contact with the blastocyst's inner surface do not.

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It was concluded that at these stages cell position could determine the development of blastomeres and the segregation of morphogenetic factors at the 4- and 8-cell stages of mouse development.

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TLDR
The results suggest that the morphogenetic movements of these early embryonic cells are principally governed by continuous cell interactions after fertilization.

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TLDR
Observations suggest that morphogenesis involves the activation of a developmental program which coordinately controls cortical cytoplasmic and cell surface organization in embryogenesis.

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TLDR
Although no trophoblast was formed, 3 1/2-day ICMs formed an outer endoderm layer after 1 day in the oviduct, as judged by light and electron microscopical evidence, and it is suggested that cell position may be important inendoderm differentiation.

Cytoplasmic polarity develops at compaction in rat and mouse embryos.

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TLDR
Although cells of the mouse morula lack the blatant asymmetric distribution of organelles observed in rat cells, a long pulse of HRP to compact 8-cell mouse embryos revealed a distinct restricted localization of the enzyme not evident at earlier pre-compaction stages.