The forward genetic dissection of afferent innate immunity.

  title={The forward genetic dissection of afferent innate immunity.},
  author={Bruce Beutler and Eva Marie Y Moresco},
  journal={Current topics in microbiology and immunology},
Recognition of the microbial world is mediated chiefly by a small group of immune receptors that activate a characteristic host inflammatory response, the innate immune response. Known as the Toll-like receptors (TLRs), these molecules are represented among most metazoans. In mammals, forward genetic analysis of the lipopolysaccharide (LPS) response led to the identification of TLR4 as the LPS receptor. Through a combination of forward and reverse genetic studies, a relatively detailed… CONTINUE READING
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