The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis

@article{Prevete2015TheFP,
  title={The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis},
  author={Nella Prevete and Federica Liotti and Carla Visciano and Gianni Marone and Rosa Marina Melillo and Amato de Paulis},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={3826-3838}
}
N-formyl peptide receptors (FPR1, FPR2 and FPR3) are involved in innate immunity, inflammation and cancer. FPR expression, initially described in immune cells, was later observed in non-hematopoietic cell populations and tissues. Several studies suggested a role for FPRs in the progression of various tumor histotypes, including gastric cancer (GC), for which a positive association with a specific FPR1 polymorphism has recently been described. We previously showed that FPRs are expressed on… CONTINUE READING
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