The formation of tubular structures by endothelial cells is under the control of fibrinolysis and mechanical factors

@article{Vailh1998TheFO,
  title={The formation of tubular structures by endothelial cells is under the control of fibrinolysis and mechanical factors},
  author={Bruno Vailh{\'e} and Marc Lecomte and Nicolas F. Wiernsperger and L{\'e}one Tranqui},
  journal={Angiogenesis},
  year={1998},
  volume={2},
  pages={331-344}
}
This study highlights the importance of several factors involved in the formation of capillary-like structure formation (CLS) using Human Umbilical Vein Endothelial Cells (HUVEC) and Bovine Retinal Endothelial Cells (BREC) cultured on fibrin gels. The fibrin concentration inducing (CLS) was 0.5 mg/ml for HUVEC and 8 mg/ml for BREC. The high fibrin concentration required for the latter cells appeared necessary to counterbalance the extensive fibrinolysis of the gel by the BREC. Fibrin… CONTINUE READING

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