The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP

@article{Araya2004TheFO,
  title={The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP},
  author={Roberto Araya and Manuel A. Riquelme and Enrique Brandan and Juan C S{\'a}ez},
  journal={Brain Research Reviews},
  year={2004},
  volume={47},
  pages={174-188}
}
Skeletal muscle differentiation follows an organized sequence of events including commitment, cell cycle withdrawal, and cell fusion to form multinucleated myotubes. The role of adenosine 5'-triphosphate (ATP)-mediated signaling in differentiation of skeletal muscle myoblasts was evaluated in C(2)C(12) cells, a myoblast cell line. Cell differentiation was inhibited by P2X receptor blockers or by degradation of endogenous ATP with apyrase. However, pertussis toxin, known to block only a group of… CONTINUE READING
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