The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog.

@article{Brenneman1972TheFO,
  title={The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog.},
  author={D. Brenneman and W. Connor and E. L. Forker and L. Denbesten},
  journal={The Journal of clinical investigation},
  year={1972},
  volume={51 6},
  pages={
          1495-503
        }
}
To study the pathogenesis of cholesterol gallstones, we fed 24 adult male prairie dogs a high cholesterol, egg yolk diet. 13 control animals received a cholesterol-free diet. All animals fed the egg yolk diet formed multiple gallstones in 2-6 months' time. These stones contained cholesterol, 77+/-14% by dry weight. No stones ocurred in the control group. The egg yolk-fed animals developed bile of altered chemical composition. The cholesterol concentration of hepatic and gallbladder bile… Expand
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