The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog.

@article{Brenneman1972TheFO,
  title={The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog.},
  author={D. Brenneman and W. Connor and E. L. Forker and L. Denbesten},
  journal={The Journal of clinical investigation},
  year={1972},
  volume={51 6},
  pages={
          1495-503
        }
}
To study the pathogenesis of cholesterol gallstones, we fed 24 adult male prairie dogs a high cholesterol, egg yolk diet. 13 control animals received a cholesterol-free diet. All animals fed the egg yolk diet formed multiple gallstones in 2-6 months' time. These stones contained cholesterol, 77+/-14% by dry weight. No stones ocurred in the control group. The egg yolk-fed animals developed bile of altered chemical composition. The cholesterol concentration of hepatic and gallbladder bile… Expand
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Early changes in bile composition and gallstone formation induced by a high cholesterol diet in prairie dogs.
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Increased biliary calcium in cholesterol and pigment gallstone disease: The role of altered bile acid composition
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Increased dietary fat content accelerates cholesterol gallstone formation in the cholesterol‐fed prairie dog
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Increased biliary cholesterol secretion in alloxan diabetic mice
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The relationship of cholecystectomy and taurocholic acid feeding to bile composition and hepatocyte function in prairie dogs.
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Effects of dietary cholesterol on bile formation and hepatic processing of chylomicron remnant cholesterol in the rat
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Mechanism of lithogenic bile production: studies in the hamster fed an essential fatty acid-deficient diet.
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Altered gallbladder concentration of biliary lipids during early cholesterol gallstone formation
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Dietary fat alters the distribution of cholesterol between vesicles and micelles in hamster bile
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Bilirubin monoglucuronide promotes cholesterol gallstone formation.
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References

SHOWING 1-10 OF 23 REFERENCES
Alimentary production of gallstones in hamsters
  • 26
INDUCTION OF GALLSTONES IN MICE BY FEEDING A CHOLESTEROL-CHOLIC ACID CONTAINING DIET.
  • 125
Gallstone Formation and Intake of B Vitamins in Cholesterol-Fed Guinea Pig
  • 16
The physicochemical basis of cholesterol gallstone formation in man.
  • 935
  • PDF
Composition of gallstone and bile: species difference.
  • F. Nakayama
  • Chemistry, Medicine
  • The Journal of laboratory and clinical medicine
  • 1969
  • 41
PHYSICOCHEMICAL CHARACTERISTICS OF BILE AND THEIR RELATION TO GALLSTONE FORMATION.
  • K. Juniper
  • Medicine
  • The American journal of medicine
  • 1965
  • 33
Increased reflux of bile into the stomach in patients with gastric ulcer.
  • 341
Cholesterol Solubilization by Solutions of Bile Salts and Bile Salts Plus Lecithin∗
  • D. Neiderhiser, H. Roth
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1968
  • 66
Concentrations of bile salts at the critical micellar concentration of human gall bladder bile.
  • 25
Experimental Formation of Gallstones in the Squirrel Monkey 1
  • 38
...
1
2
3
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