The formation and persistence of carboplatin-DNA adducts in rats

@article{Blommaert1996TheFA,
  title={The formation and persistence of carboplatin-DNA adducts in rats},
  author={F. A. Blommaert and C. Michael and H. C. van Dijk-Knijnenburg and J. Schornagel and L. den Engelse and A. Fichtinger-Schepman},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1996},
  volume={38},
  pages={273-280}
}
Abstract The formation and persistence of platinum-DNA adducts were studied with immuno(cyto)chemical methods in male and female Sprague-Dawley rats treated with a single i.p. dose of carboplatin. Linear dose-effect curves were observed for kidney and liver with an immunocytochemical assay using NKI-A59 antiserum that recognizes intrastrand cross-links. With this method, no staining of the nuclei due to platinum-DNA damage could be observed in the spleen, testis, uterus, or ovary after… Expand
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