The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

  title={The formalin test in mice: dissociation between inflammatory and non-inflammatory pain},
  author={Steinar Hunskaar and Kjell J{\o}rgen Hole},

Standardization of the rat paw formalin test for the evaluation of analgesics

The relative involvement of spinal (as opposed to supraspinal) processing of noxious inputs may be a function of stimulus intensity and underlie the differences in antinociceptive potency observed in this work.

Application of the Formalin Test to the Study of Orofacial Pain in the Rat.

In this experiment, a modification of the formalin test for assessing pain and analgesia in the orofacial region is described in the rat and the results indicate that this o rofacial formalIn test is a valid technique for the study of oroFacial pain.

The formalin test: an evaluation of the method

Analgesic effectiveness of ketorolac compared to meperidine in the rat formalin test.

The rat formalin test is an analgesic behavioral observation assessment method that demonstrates two phases of nociceptive behavior and ketorolac, when compared to meperidine, is less effective in treating pain from inflammatory origin and is not effective inreating pain from direct nerve stimulation.



Similar effects of acetylsalicylic acid and morphine on immediate responses to acute noxious stimulation.

  • S. Hunskaar
  • Biology, Medicine
    Pharmacology & toxicology
  • 1987
No delay of onset in the action of ASA compared to morphine could be demonstrated, and ASA seems to be antinociceptive also in acute non-inflammatory pain.

Inhibition of electrically-induced vocalization in adjuvant arthritic rats as a novel method for evaluating analgesic drugs.

A new method for the evaluation of analgesic drugs in normal rats and in rats with hyperalgesia induced by adjuvant was developed using the vocalization response as an indicator of pain due to electrical shock, and it was suggested that the acidic NSAIDs specifically inhibit inflammatory pain.

Biphasic development of carrageenin edema in rats.

The discovery that carrageenin was charred by heat treatment at 130°C for 16 hr, it elicited the full first phase edema volume without subsequent development of the second phase indicates that the secondphase is not a consequence of processes initiated during the first phase but is dependent on the structural integrity of the irritant molecule.

Antinociceptive effects of orphenadrine citrate in mice.