The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

@article{Hunskaar1987TheFT,
  title={The formalin test in mice: dissociation between inflammatory and non-inflammatory pain},
  author={Steinar Hunskaar and Kjell J{\o}rgen Hole},
  journal={Pain},
  year={1987},
  volume={30},
  pages={103-114}
}
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2,140 Citations
Highly Influential Citations
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2,140 Citations

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Analgesic effectiveness of ketorolac compared to meperidine in the rat formalin test.

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References

SHOWING 1-10 OF 52 REFERENCES

Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test

Formalin test in mice, a useful technique for evaluating mild analgesics

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

Similar effects of acetylsalicylic acid and morphine on immediate responses to acute noxious stimulation.

  • S. Hunskaar
  • Biology, Medicine
    Pharmacology & toxicology
  • 1987
No delay of onset in the action of ASA compared to morphine could be demonstrated, and ASA seems to be antinociceptive also in acute non-inflammatory pain.

Changes in nociception after lesions of descending serotonergic pathways induced with 5,6-dihydroxytryptamine Different effects in the formalin and tail-flick tests

Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain

A modified hot-plate test sensitivie to mild analgesics

Inhibition of electrically-induced vocalization in adjuvant arthritic rats as a novel method for evaluating analgesic drugs.

A new method for the evaluation of analgesic drugs in normal rats and in rats with hyperalgesia induced by adjuvant was developed using the vocalization response as an indicator of pain due to electrical shock, and it was suggested that the acidic NSAIDs specifically inhibit inflammatory pain.

Biphasic development of carrageenin edema in rats.

The discovery that carrageenin was charred by heat treatment at 130°C for 16 hr, it elicited the full first phase edema volume without subsequent development of the second phase indicates that the secondphase is not a consequence of processes initiated during the first phase but is dependent on the structural integrity of the irritant molecule.

Antinociceptive effects of orphenadrine citrate in mice.

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