The fork head domain: A novel DNA binding motif of eukaryotic transcription factors?

  title={The fork head domain: A novel DNA binding motif of eukaryotic transcription factors?},
  author={Detlef Weigel and Herbert Jäckle},

The role of Oct4 in murine endoderm development

It is shown that Oct4 function is also important for proper formation of hindgut endoderm and correct left-right axis establishment through the modulation of the Wnt and Tgf-β signaling pathways by Oct4.

Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2

It is established that Foxk1 promotes MPC proliferation by repressed Foxo4 transcriptional activity and inhibits myogenic differentiation by repressing Mef2 activity, which enhances the understanding of the transcriptional networks that regulate the MPC population and muscle regeneration.

Pintallavis , a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis

notochord. Overexpression of Pintallavis perturbs the development of the neural axis, suppressing the differentiation of anterior and dorsal neural cell types but caus-ing an expansion of the

Formation of the chordamesoderm in the amphioxus embryo: Analysis with Brachyury and fork head/HNF-3 genes

Investigation of the formation of the chordamesoderm in amphioxus embryos using the genes Brachyury and fork head/HNF-3 as probes shows similarity and dissimilarity with that of the notochord and tail bud in vertebrate embryos.

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.

Results suggest that HNF-3 beta and H NF-3 alpha, in addition to their known functions as transcriptional activators in adult liver, play a role in body axis formation, neural tube patterning and definitive endoderm formation during gastrulation.

Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients—A Genetic Cohort Study

The carriers of a C allele in ANGPTL6 rs8112063, FOXO3 rs4946936, DOCK6 rs737337, and rs17699089 nucleotide variants are predictors of survival in patients undergoing HD.

P2Y2R-Mediated PAK1 Activation Is Involved in ESM-1 Overexpression in RT-R-MDA-MB-231 through FoxO1 Regulation

The results demonstrate, for the first time, that ESM-1 overexpressed in RT-R-MDA-MB-231 cells is regulated through the P2Y2R-PAK1-FoxO1 signaling pathway, and suggest that targeting this pathway may be a new therapeutic target for patients with TNBC who acquireRT-R and may improve their prognosis.

A comprehensive study of arthropod and onychophoran Fox gene expression patterns

The data show that many of the Fox genes likely retained their function during panarthropod evolution highlighting their importance in development, and comparison with published data from other groups of animals shows that this high degree of evolutionary conservation often dates back beyond the last common ancestor of Panarthropoda.

FOXO transcription factors differ in their dynamics and intra/intermolecular interactions




HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

The mRNA for HNF-3A is present in the rat liver but not in brain, kidney, intestine, or spleen, and the basis for this difference is cell-specific regulation of HNF -3A gene transcription.

The molecular genetics of embryonic pattern formation in Drosophila

Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two