The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly

@article{Labb2004TheFT,
  title={The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly},
  author={Jean-Claude Labb{\'e} and Erin K. McCarthy and Bob Goldstein},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={167},
  pages={245 - 256}
}
Regulation of the mitotic spindle's position is important for cells to divide asymmetrically. Here, we use Caenorhabditis elegans embryos to provide the first analysis of the temporal regulation of forces that asymmetrically position a mitotic spindle. We find that asymmetric pulling forces, regulated by cortical PAR proteins, begin to act as early as prophase and prometaphase, even before the spindle forms and shifts to a posterior position. The spindle does not shift asymmetrically during… CONTINUE READING