The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster

@article{Waters1993TheFM,
  title={The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster},
  author={Johnn D Waters and Richard W. Cole and Conly L. Rieder},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={122},
  pages={361 - 372}
}
A popular hypothesis for centrosome separation during spindle formation and anaphase is that pushing forces are generated between interacting microtubules (MTs) of opposite polarity, derived from opposing centrosomes. However, this mechanism is not consistent with the observation that centrosomes in vertebrate cells continue to separate during prometaphase when their MT arrays no longer overlap (i.e., during anaphase-like prometaphase). To evaluate whether centrosome separation during prophase… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 55 references

Astral and spindle forces in mitotic PtK 2 cells . A laser microbeam study

H. Liang
J . Cell Sci . • 1993

Direct ex - perirnental evidence for the existence , structural basis and function of astral forces during anaphase B in vivo

W. Tao, M. W. Berns
J . Cell Sci . • 1991

Mitotic Motors

T. J. Mitehison
J . Cell Biol . • 1991

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