The food contaminant semicarbazide acts as an endocrine disrupter: Evidence from an integrated in vivo/in vitro approach.

@article{Maranghi2010TheFC,
  title={The food contaminant semicarbazide acts as an endocrine disrupter: Evidence from an integrated in vivo/in vitro approach.},
  author={Francesca Maranghi and Roberta Tassinari and Daniele Marcoccia and Ilaria Altieri and Tiziana Catone and Giovanna De Angelis and Emanuela Testai and Sabina Mastrangelo and Maria Grazia Evandri and Paola Bolle and Stefano Lorenzetti},
  journal={Chemico-biological interactions},
  year={2010},
  volume={183 1},
  pages={40-8}
}
Semicarbazide (SEM) is a by-product of the blowing agent azodicarbonamide, present in glass jar-sealed foodstuffs mainly baby foods. The pleiotropic in vivo SEM toxicological effects suggested to explore its possible role as endocrine modulator. Endocrine effects of SEM were assessed in vivo in male and female rats after oral administration for 28 days at 0, 40, 75, 140mg/kg bw pro die during the juvenile period. Vaginal opening and preputial separation were recorded. Concentration of sex… CONTINUE READING

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