The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

@article{Tsun2013TheFT,
  title={The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.},
  author={Zhi-Yang Tsun and Liron Bar-Peled and Lynne Chantranupong and Roberto Zoncu and Tim Wang and Choah Kim and Eric Spooner and David M. Sabatini},
  journal={Molecular cell},
  year={2013},
  volume={52 4},
  pages={495-505}
}
The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting the translocation of mTORC1 to the lysosomal surface, its site of activation. The Rags are unusual GTPases in that they function as obligate heterodimers, which consist of RagA or B bound to RagC or D. While the loading of RagA/B with GTP initiates amino acid signaling to mTORC1, the role of RagC/D is… CONTINUE READING
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