The folding pathway of alpha1-antitrypsin: avoiding the unavoidable.

  title={The folding pathway of alpha1-antitrypsin: avoiding the unavoidable.},
  author={Stephen P. Bottomley},
  journal={Proceedings of the American Thoracic Society},
  volume={7 6},
  • Stephen P. Bottomley
  • Published in
    Proceedings of the American…
  • Chemistry, Medicine
  • Understanding the folding pathway of α(1)-antitrypsin is of interest from both biomedical and fundamental molecular biology perspectives. The native fold of α(1)-antitrypsin is metastable, and therefore does not represent the most stable conformation that its primary sequence can adopt. More stable conformations are formed when the reactive center loop inserts, as the fourth strand, into the A β sheet. The accessibility of these alternative low-energy folds renders α(1)-antitrypsin susceptible… CONTINUE READING

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