The folding and evolution of multidomain proteins

  title={The folding and evolution of multidomain proteins},
  author={Jung-Hoon Han and S. Batey and Adrian A. Nickson and S. Teichmann and J. Clarke},
  journal={Nature Reviews Molecular Cell Biology},
  • Jung-Hoon Han, S. Batey, +2 authors J. Clarke
  • Published 2007
  • Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • Analyses of genomes show that more than 70% of eukaryotic proteins are composed of multiple domains. However, most studies of protein folding focus on individual domains and do not consider how interactions between domains might affect folding. Here, we address this by analysing the three-dimensional structures of multidomain proteins that have been characterized experimentally and observe that where the interface is small and loosely packed, or unstructured, the folding of the domains is… CONTINUE READING
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