The folding and evolution of multidomain proteins

@article{Han2007TheFA,
  title={The folding and evolution of multidomain proteins},
  author={Jung-Hoon Han and Sarah Batey and Adrian A. Nickson and Sarah A. Teichmann and Jane Clarke},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={319-330}
}
Analyses of genomes show that more than 70% of eukaryotic proteins are composed of multiple domains. However, most studies of protein folding focus on individual domains and do not consider how interactions between domains might affect folding. Here, we address this by analysing the three-dimensional structures of multidomain proteins that have been characterized experimentally and observe that where the interface is small and loosely packed, or unstructured, the folding of the domains is… Expand

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