The foldability landscape of model proteins.

  title={The foldability landscape of model proteins.},
  author={Sridhar Govindarajan and Richard A. Goldstein},
  volume={42 4},
Molecular evolution may be considered as a walk in a multidimensional fitness landscape, where the fitness at each point is associated with features such as the function, stability, and survivability of these molecules. We present a simple model for the evolution of protein sequences on a landscape with a precisely defined fitness function. We use simple lattice models to represent protein structures, with the ability of a protein sequence to fold into the structure with lowest energy… CONTINUE READING