The focal adhesion phosphoprotein, VASP.

  title={The focal adhesion phosphoprotein, VASP.},
  author={Mark Holt and David R. Critchley and Nicholas P. J. Brindle},
  journal={The international journal of biochemistry & cell biology},
  volume={30 3},
Vasodilator-stimulated phosphoprotein (VASP) is associated with focal adhesions and areas of dynamic membrane activity, where it is thought to have an important role in actin filament assembly and cell motility. VASP contains a central proline-rich sequence which recruits the G-actin binding protein profilin. Localization of VASP to the leading edge of a migrating cell can lead to local accumulation of profilin, which in turn can supply actin monomers to growing filament ends. VASP binds to the… CONTINUE READING