The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma

  title={The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma},
  author={Orlie Kahana and Michael Micksche and Isaac P Witz and Ilana Yron},
Malignant melanoma cells show high aggressiveness and metastatic potential. Tumor cells as they become more metastatic, gradually lose their dependence on both adhesion and serum. Thus, in the process of tumor progression cells undergo series of changes that allow them to adapt to different tissue milieu. This implies that during this process, points on the integrin pathway may become constitutively activated. In the present study we investigated the possible role of FAK, being one of the key… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 32 extracted citations


Publications referenced by this paper.
Showing 1-4 of 4 references


Parsons JT.
J., 324, 141 ± 149. Ridley A. (2000). Rho GTPases J. Cell Res., 150, F107 ± • 1997


W Berger, E Hauptmann, +3 authors M. Micksche
J. Cancer, 71, 108 ± 115. • 1997


AP Gilmore, Romer LH.
Biol. Cell, 7, 1209 ± 1224. • 1996


C Guinebault, B Payastre, +5 authors H. Chap
Cell Biol., 129, 831 ± 842. • 1995

Similar Papers

Loading similar papers…