The fluorinase, the chlorinase and the duf-62 enzymes.

  title={The fluorinase, the chlorinase and the duf-62 enzymes.},
  author={Hai Deng and David O'Hagan},
  journal={Current opinion in chemical biology},
  volume={12 5},
The fluorinase from Streptomyces cattleya and chlorinase from Salinispora tropica have a commonality in that they mediate nucleophilic reactions of their respective halide ions to the C-5' carbon of S-adenosyl-L-methionine (SAM). These enzyme reactions fall into the relatively small group of S(N)2 substitution reactions found in enzymology. These enzymes have some homology to a larger class of proteins expressed by the duf-62 gene, of which around 200 representatives have been sequenced and… CONTINUE READING