• Biology, Medicine
  • Published in Stem cells 1994

The flt3 ligand: a hematopoietic stem cell factor whose activities are distinct from steel factor.

@article{Lyman1994TheFL,
  title={The flt3 ligand: a hematopoietic stem cell factor whose activities are distinct from steel factor.},
  author={Stewart D. Lyman and Kenneth A. Brasel and Alain Rousseau and Douglas E. Williams},
  journal={Stem cells},
  year={1994},
  volume={12 Suppl 1},
  pages={
          99-107; discussion 108-10
        }
}
A number of growth factors have been described that affect the hematopoietic system. Among this group are Steel factor (also known as mast cell growth factor, stem cell factor and kit ligand), and the more recently described flt3 ligand. These factors have been shown to function by binding to and activating the c-kit and flt3 tyrosine kinase receptors, respectively. Both of these factors stimulate the growth of mouse and human hematopoietic progenitor cells. These factors therefore differ from… CONTINUE READING

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