The flinders sensitive line rat model of depression--25 years and still producing.

@article{Overstreet2013TheFS,
  title={The flinders sensitive line rat model of depression--25 years and still producing.},
  author={David H. Overstreet and Gregers Wegener},
  journal={Pharmacological reviews},
  year={2013},
  volume={65 1},
  pages={
          143-55
        }
}
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal paper, and there has been a steady stream of publications (130+) over the years. The present review will focus on several issues not previously covered in earlier reviews, summarize the several lines of ongoing investigations, and propose a novel mechanism that accounts for a… CONTINUE READING

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