The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.

@article{Silva2017TheFR,
  title={The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.},
  author={Alessandra Bispo da Silva and Paulo Lucas Cerqueira Coelho and Jessika Alves Oliveira Amparo and Monique Marylin Alves de Almeida Carneiro and Julita Maria Pereira Borges and Cleide dos Santos Souza and Maria de F{\'a}tima Dias Costa and Miriam Mecha and Carmen Guaza Rodriguez and Victor Di{\'o}genes Amaral da Silva and Silvia Lima Costa},
  journal={Chemico-biological interactions},
  year={2017},
  volume={274},
  pages={
          89-99
        }
}
Rutin is a glycosylated flavonoid present in many fruits and plants that has been demonstrated to have anti-inflammatory and antioxidant properties. However, little is known about the mechanisms underlying microglial activation and its effects on the regulation of cytokines and chemokines associated with inflammatory responses in the central nervous system. In this study we examined the effect of rutin on resting or lipopolysaccharide (LPS)-stimulated microglia and characterized their… CONTINUE READING