The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets.

@article{Stangl2005TheFP,
  title={The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets.},
  author={Verena Stangl and Mario Lorenz and Antje Ludwig and Nicole Grimbo and Carola Guether and Wasiem Sanad and Sabine Ziemer and Peter Martus and Gert Baumann and Karl Stangl},
  journal={The Journal of nutrition},
  year={2005},
  volume={135 2},
  pages={172-8}
}
Atherosclerosis is a chronic inflammatory disease accompanied by the expression of endothelial adhesion molecules. Phloretin is a plant-derived phytochemical that is mainly present in apples. Because phloretin is reported to promote antioxidative activities, we investigated the effects of phloretin on cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule-1 (E-selectin) in human umbilical… CONTINUE READING

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