The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.

@article{Gelderblom2012TheFF,
  title={The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.},
  author={Mathias Gelderblom and Frank Leypoldt and Jan Lewerenz and Gabriel Birkenmayer and Denise Orozco and Peter Ludewig and John Thundyil and Thiruma Valavan Arumugam and Christian Gerloff and E. M. de Tolosa and Pamela Maher and Tim Magnus},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2012},
  volume={32 5},
  pages={835-43}
}
The development of the brain tissue damage in ischemic stroke is composed of an immediate component followed by an inflammatory response with secondary tissue damage after reperfusion. Fisetin, a flavonoid, has multiple biological effects, including neuroprotective and antiinflammatory properties. We analyzed the effects of fisetin on infarct size and the inflammatory response in a mouse model of stroke, temporary middle cerebral artery occlusion, and on the activation of immune cells, murine… CONTINUE READING

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