The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia.

@article{Clarkson2018TheF2,
  title={The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia.},
  author={Andrew N. Clarkson and Lily Boothman-Burrell and Zita J Dosa and Raghavendra Y Nagaraja and Liang Jin and Kim H. Parker and Petra S. van Nieuwenhuijzen and Silke Neumann and Emma K. Gowing and Navnath Gavande and Philip Ki{\ae}r Ahring and Mai Marie Holm and Jane R. Hanrahan and Joseph A Nicolazzo and Kimmo Jensen and Mary Chebib},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2018},
  pages={
          271678X18755628
        }
}
Tonic inhibitory currents, mediated by extrasynaptic GABAA receptors, are elevated at a delay following stroke. Flavonoids minimise the extent of cellular damage following stroke, but little is known about their mode of action. We demonstrate that the flavonoid, 2'-methoxy-6-methylflavone (0.1-10 µM; 2'MeO6MF), increases GABAA receptor tonic currents… CONTINUE READING