The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure.

@article{Issur2009TheFN,
  title={The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure.},
  author={Moheshwarnath Issur and Brian J. Geiss and Isabelle Bougie and Fr{\'e}d{\'e}ric Picard-Jean and Simon Despins and Joannie Mayette and Sarah E. Hobdey and Martin Bisaillon},
  journal={RNA},
  year={2009},
  volume={15 12},
  pages={
          2340-50
        }
}
The 5'-end of the flavivirus genome harbors a methylated (m7)GpppA(2'OMe) cap structure, which is generated by the virus-encoded RNA triphosphatase, RNA (guanine-N7) methyltransferase, nucleoside 2'-O-methyltransferase, and RNA guanylyltransferase. The presence of the flavivirus guanylyltransferase activity in NS5 has been suggested by several groups but has not been empirically proven. Here we provide evidence that the N-terminus of the flavivirus NS5 protein is a true RNA guanylyltransferase… CONTINUE READING
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