The flavin-containing monooxygenases in rat liver: evidence for the expression of a second form different from FMO1.

@article{Moroni1995TheFM,
  title={The flavin-containing monooxygenases in rat liver: evidence for the expression of a second form different from FMO1.},
  author={Pier Giorgio Prada Moroni and Christiane Longin-Sauvageon and Etienne Beno{\^i}t},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={212 3},
  pages={820-6}
}
A second form of rat liver FMO, FMO-A, was separated and purified by chromatography on Blue Sepharose Fast flow 6. This FMO-A is different from FMO1 by antigenic properties (anti-FMO-A did not cross-react with FMO1, and reciprocally) and by catalytic properties (the Km for trimethylamine was 3.8 microM and 141.4 microM for FMO-A and FMO1, respectively; the Km for imipramine was 536 microM and 17.4 microM for FMO-A and FMO1, respectively). Furthermore, N-terminal amino sequencing revealed… CONTINUE READING

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