The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells.

@article{Ren2007TheFG,
  title={The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells.},
  author={Nan Ren and Jeannette Charlton and Paul N Adler},
  journal={Genetics},
  year={2007},
  volume={176 4},
  pages={2223-34}
}
Adult Drosophila are decorated with several types of polarized cuticular structures, such as hairs and bristles. The morphogenesis of these takes place in pupal cells and is mediated by the actin and microtubule cytoskeletons. Mutations in flare (flr) result in grossly abnormal epidermal hairs. We report here that flr encodes the Drosophila actin interacting protein 1 (AIP1). In other systems this protein has been found to promote cofilin-mediated F-actin disassembly. In Drosophila cofilin is… CONTINUE READING

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A subset of dynamic actin rearrangements in Drosophila requires the Arp 2 / 3 complex

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