The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway.

@article{Claret2007TheFS,
  title={The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway.},
  author={Laurent Claret and Sylvie Miquel and Natacha Vieille and Dmitri A. Ryjenkov and Mark Gomelsky and Arlette Darfeuille-Michaud},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 46},
  pages={33275-83}
}
The invasion of intestinal epithelial cells by the Crohn disease-associated adherent-invasive Escherichia coli (AIEC) strain LF82 depends on surface appendages, such as type 1 pili and flagella. The absence of flagella in the AIEC strain LF82 results in a concomitant loss of type 1 pili. Here, we show that flagellar regulators, transcriptional activator FlhD(2)C(2), and sigma factor FliA are involved in the coordination of flagellar and type 1 pili synthesis. In the deletion mutants lacking… CONTINUE READING

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FliA, c-di-GMP and Adherent-Invasive E. coli

P. E. Orndorff, S. Falkow
J. Bacteriol • 1984

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