The fixation probability of rare mutators in finite asexual populations.

@article{Wylie2009TheFP,
  title={The fixation probability of rare mutators in finite asexual populations.},
  author={Calvin J. S. Wylie and Cheol-Min Ghim and David A. Kessler and Herbert Levine},
  journal={Genetics},
  year={2009},
  volume={181 4},
  pages={1595-612}
}
A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100-fold have been observed to spontaneously emerge and achieve high frequencies in natural populations and in long-term laboratory evolution experiments with Escherichia coli. In principle, the fixation of mutator alleles is limited by (i) competition with mutations in wild-type backgrounds, (ii… CONTINUE READING

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