The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

@inproceedings{Saudemont2017TheFC,
  title={The fitness cost of mis-splicing is the main determinant of alternative splicing patterns},
  author={Baptiste Saudemont and Alexandra Popa and Joanna L. Parmley and Vincent Rocher and Corinne Blugeon and Anamaria Necşulea and E. Meyer and Laurent Duret},
  booktitle={Genome Biology},
  year={2017}
}
Most eukaryotic genes are subject to alternative splicing (AS), which may contribute to the production of protein variants or to the regulation of gene expression via nonsense-mediated messenger RNA (mRNA) decay (NMD). However, a fraction of splice variants might correspond to spurious transcripts and the question of the relative proportion of splicing… CONTINUE READING
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