The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

@article{Ottilie1992TheFY,
  title={The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.},
  author={Sabine Ottilie and Jonathan Chernoff and Gerhard Hannig and Charles S Hoffman and Raymond Leo Erikson},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 12},
  pages={5571-80}
}
We have used degenerate oligonucleotide probes based on sequences conserved among known protein tyrosine phosphatases (PTPases) to identify two Schizosaccharomyces pombe genes encoding PTPases. We previously described the cloning of pyp1+ (S. Ottilie, J. Chernoff, G. Hannig, C. S. Hoffman, and R. L. Erikson, Proc. Natl. Acad. Sci. USA 88:3455-3459, 1991), and here we describe a second gene, called pyp2+. The C terminus of each protein contains sequences conserved in the apparent catalytic… CONTINUE READING