The firstH- 2 mutant workshop

  title={The firstH- 2 mutant workshop},
  author={Henry I. Kohn and J. Klein and Roger W. Melvold and Stanley G. Nathenson and Donald A. Pious and Donald C. Shreffler},
The major accomplishment of the Workshop was probably the realization of many of its participants that most of the 21 availableH- 2 variants aretrue mutations very likely derived from single nucleotide substitutions. Any theory of the pleiotropic effect of theH- 2 genes must now take this fact into account; such theories must also consider the observation that a wide variety of immunological phenomena are affected byH- 2 mutations and thus, apparently, are controlled by a single gene. 

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