The first untranslated exon of the human tenascin-C gene plays a regulatory role in gene transcription.

@article{Gherzi1995TheFU,
  title={The first untranslated exon of the human tenascin-C gene plays a regulatory role in gene transcription.},
  author={Roberto Gherzi and Marco Ponassi and B Gaggero and Luciano Zardi},
  journal={FEBS letters},
  year={1995},
  volume={369 2-3},
  pages={335-9}
}
The transcription of the human tenascin-C (TN-C) gene is directed by a single promoter. Here we demonstrate, in transiently transfected cells, that two distinct regions of the untranslated 179 bp-long exon 1 play antagonistic roles in transcriptional regulation: bases from 1 to 20 strongly increase the transcription of the reporter gene CAT directed by the… CONTINUE READING