The first total synthesis of the cyclodepsipeptide pipecolidepsin A.

@article{PelayGimeno2013TheFT,
  title={The first total synthesis of the cyclodepsipeptide pipecolidepsin A.},
  author={Marta Pelay-Gimeno and Yesica Garcia-Ramos and M. Jes{\'u}s Martin and J. Spengler and J. M. Molina-Guijarro and S. Munt and A. Francesch and C. Cuevas and Judit Tulla-Puche and F. Albericio},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={
          2352
        }
}
Pipecolidepsin A is a head-to-side-chain cyclodepsipeptide isolated from the marine sponge Homophymia lamellosa. This compound shows relevant cytotoxic activity in three human tumour cell lines and has unique structural features, with an abundance of non-proteinogenic residues, including several intriguing amino acids. Although the moieties present in the structure show high synthetic difficulty, the cornerstone is constituted by the unprecedented and highly hindered γ-branched β-hydroxy… Expand
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