The first total synthesis of the cyclodepsipeptide pipecolidepsin A.

@article{PelayGimeno2013TheFT,
  title={The first total synthesis of the cyclodepsipeptide pipecolidepsin A.},
  author={Marta Pelay-Gimeno and Yesica Garcia-Ramos and Maria Jes{\'u}s Martin and Jan Spengler and Jos{\'e} Manuel Molina-Guijarro and Simon Munt and Andr{\'e}s M Francesch and Carmen Cuevas and Judit Tulla-Puche and Fernando Albericio},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={
          2352
        }
}
Pipecolidepsin A is a head-to-side-chain cyclodepsipeptide isolated from the marine sponge Homophymia lamellosa. This compound shows relevant cytotoxic activity in three human tumour cell lines and has unique structural features, with an abundance of non-proteinogenic residues, including several intriguing amino acids. Although the moieties present in the structure show high synthetic difficulty, the cornerstone is constituted by the unprecedented and highly hindered γ-branched β-hydroxy… CONTINUE READING

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