The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage.

Abstract

Enediyne antitumor antibiotics have attracted immense attention among chemists and biologists alike because of their unique chemical structures, potent antitumor activities, and fascinating biological modes of action.1 As a novel addition to this family, the nonprotein and extremely strained nine-membered enediyne antibiotic N1999-A2 strongly inhibits the… (More)

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Cite this paper

@article{Kobayashi2001TheFT, title={The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage.}, author={S. Kobayashi and Satoshi Ashizawa and Y. Takahashi and Y. Sugiura and Makio Nagaoka and M. J. Lear and Masahiro Hirama}, journal={Journal of the American Chemical Society}, year={2001}, volume={123 45}, pages={11294-5} }