The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.

@article{Lou2006TheFT,
  title={The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.},
  author={Meizhen Lou and Thomas P. J. Garrett and Neil M. McKern and Peter A. Hoyne and Vidana Chandana Epa and John D. Bentley and George O. Lovrecz and Leah J. Cosgrove and Maurice J. Frenkel and Colin W. Ward},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 33},
  pages={12429-34}
}
The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with differing specificity. Here we report the crystal structure of the first three domains (L1-CR-L2) of human IR at 2.3 A resolution and compare it with the previously determined structure of the corresponding fragment of IGF1R. The most important differences seen between the two receptors are in the two regions governing ligand specificity. The… CONTINUE READING
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