Corpus ID: 20217220

The first organoantimony(III) compounds possessing antitumor properties: diphenylantimony(III) derivatives of dithiophosphorus ligands.

@article{Silvestru1990TheFO,
  title={The first organoantimony(III) compounds possessing antitumor properties: diphenylantimony(III) derivatives of dithiophosphorus ligands.},
  author={C. Silvestru and C. Socaciu and A. Bara and I. Haiduc},
  journal={Anticancer research},
  year={1990},
  volume={10 3},
  pages={
          803-4
        }
}
Two organoantimony (III) derivatives, i.e., diphenylantimony diphenyl-dithiophosphinate, Ph2SbS2PPh2, and diphenylantimony diizopropyldithiophosphate, Ph2SbS2P(OPri)2, were shown to exhibit antitumor properties. Both compounds produced strong tumor inhibition effects in mice bearing Ehrlich ascites tumor. Moreover, the dithiophosphate (15 mg/kg, i.p., in days 1, 3 and 5) produced a cure rate of 30%. 
Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds.
  • Yi Chen, Kun Yu, +7 authors S. Yin
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2014
...
1
2
3
4
5
...