The first nonsulfated sulfakinin activity reported suggests nsDSK acts in gut biology.

@article{Nichols2007TheFN,
  title={The first nonsulfated sulfakinin activity reported suggests nsDSK acts in gut biology.},
  author={Ruthann Nichols},
  journal={Peptides},
  year={2007},
  volume={28 4},
  pages={767-73}
}
Invertebrate sulfakinins are structurally and functionally homologous to vertebrate cholecystokinin (CCK) and gastrin. To date, sulfakinins are reported to require a sulfated tyrosine for activity; sulfated and nonsulfated CCK and gastrin are active. This is the first nonsulfated sulfakinin activity reported. Nonsulfated Drosophila melanogaster sulfakinins or drosulfakinins (nsDSK I; PheAspAspTyrGlyHisMetArgPheNH2) and (nsDSK II; GlyGlyAspAspGlnPheAspAspTyrGlyHisMetArgPheNH2) decreased the… CONTINUE READING