The first intestinal motility patterns in fetal mice are not mediated by neurons or interstitial cells of Cajal.

@article{Roberts2010TheFI,
  title={The first intestinal motility patterns in fetal mice are not mediated by neurons or interstitial cells of Cajal.},
  author={Rachael R Roberts and Melina Ellis and Rachel M. Gwynne and Annette J. Bergner and Martin David Lewis and Elizabeth A H Beckett and Joel C Bornstein and Heather M Young},
  journal={The Journal of physiology},
  year={2010},
  volume={588 Pt 7},
  pages={1153-69}
}
In mature animals, neurons and interstitial cells of Cajal (ICC) are essential for organized intestinal motility. We investigated motility patterns, and the roles of neurons and myenteric ICC (ICC-MP), in the duodenum and colon of developing mice in vitro. Spatiotemporal mapping revealed regular contractions that propagated in both directions from embryonic day (E)13.5 in the duodenum and E14.5 in the colon. The propagating contractions, which we termed ripples, were unaffected by tetrodotoxin… CONTINUE READING