The first gene-encoded amphibian neurotoxin.

  title={The first gene-encoded amphibian neurotoxin.},
  author={Dewen You and Jing Hong and Mingqiang Rong and Haining Yu and Songping Liang and Yufang Ma and Hailong Yang and Jing Wu and Donghai Lin and Ren Lai},
  journal={The Journal of biological chemistry},
  volume={284 33},
Many gene-encoded neurotoxins with various functions have been discovered in fish, reptiles, and mammals. A novel 60-residue neurotoxin peptide (anntoxin) that inhibited tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channel (VGSC) was purified and characterized from the skin secretions of the tree frog Hyla annectans (Jerdon). This is the first gene-encoded neurotoxin found in amphibians. The IC50 of anntoxin for the TTX-S channel was about 3.4 microM. Anntoxin shares sequence homology… CONTINUE READING


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