The first extracellular domain of corticotropin releasing factor-R1 contains major binding determinants for urocortin and astressin.

@article{Perrin1998TheFE,
  title={The first extracellular domain of corticotropin releasing factor-R1 contains major binding determinants for urocortin and astressin.},
  author={Marilyn H. Perrin and Steve W Sutton and Deborah L Bain and William Travis Berggren and Wylie W. Vale},
  journal={Endocrinology},
  year={1998},
  volume={139 2},
  pages={566-70}
}
The CRF receptors are members of a 7-transmembrane receptor family that includes GH-releasing hormone (GRF), calcitonin, vasoactive intestinal peptide (VIP), secretin, and PTH receptors. To determine the structural features of the CRF receptor that may influence ligand recognition, a series of mutant receptors was analyzed for binding to astressin, a CRF antagonist, and to urocortin, a CRF agonist. Mutant receptors included chimeras between the CRF-R1 and GRF-R or Activin IIB-R, a single… CONTINUE READING
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