The first draft of the endostatin interaction network.

  title={The first draft of the endostatin interaction network.},
  author={Cl{\'e}ment Faye and Emilie Chautard and Bjorn Reino Olsen and Sylvie Ricard-Blum},
  journal={The Journal of biological chemistry},
  volume={284 33},
Endostatin is a C-terminal proteolytic fragment of collagen XVIII that is localized in vascular basement membrane zones in various organs. It binds to heparin/heparan sulfate and to a number of proteins, but its molecular mechanisms of action are not fully elucidated. We have used surface plasmon resonance (SPR) arrays to identify new partners of endostatin, and to give further insights on its molecular mechanism of action. New partners of endostatin include glycosaminoglycans (chondroitin and… CONTINUE READING
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