The first cleavage of the mouse zygote predicts the blastocyst axis

@article{Plusa2005TheFC,
  title={The first cleavage of the mouse zygote predicts the blastocyst axis},
  author={Berenika Plusa and Anna-Katerina Hadjantonakis and Dionne J Gray and Karolina Piotrowska-Nitsche and Agnieszka Jędrusik and Virginia E Papaioannou and David M Glover and Magdalena Zernicka-Goetz},
  journal={Nature},
  year={2005},
  volume={434},
  pages={391-395}
}
One of the unanswered questions in mammalian development is how the embryonic–abembryonic axis of the blastocyst is first established. It is possible that the first cleavage division contributes to this process, because in most mouse embryos the progeny of one two-cell blastomere primarily populate the embryonic part of the blastocyst and the progeny of its sister populate the abembryonic part. However, it is not known whether the embryonic–abembryonic axis is set up by the first cleavage… CONTINUE READING

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