The first characterization of two type I interferons in turbot (Scophthalmus maximus) reveals their differential role, expression pattern and gene induction.

@article{Pereiro2014TheFC,
  title={The first characterization of two type I interferons in turbot (Scophthalmus maximus) reveals their differential role, expression pattern and gene induction.},
  author={Patricia Pereiro and Mar{\'i}a del Mar Costa and Patricia D{\'i}az-Rosales and Sonia Dios and A. Figueras and Beatriz 9 Novoa},
  journal={Developmental and comparative immunology},
  year={2014},
  volume={45 2},
  pages={233-44}
}
Type I interferons (IFNs) are considered the main cytokines directing the antiviral immune response in vertebrates. These molecules are able to induce the transcription of interferon-stimulated genes (ISGs) which, using different blocking mechanisms, reduce the viral proliferation in the host. In addition, a contradictory role of these IFNs in the protection against bacterial challenges using murine models has been observed, increasing the survival or having a detrimental effect depending on… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

The Function of Fish Cytokines

View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…