The first arrival time and mean age of a deleterious mutant gene in a finite population.

@article{Li1975TheFA,
  title={The first arrival time and mean age of a deleterious mutant gene in a finite population.},
  author={Wen Li},
  journal={American journal of human genetics},
  year={1975},
  volume={27 3},
  pages={274-86}
}
  • Wen Li
  • Published 1975 in American journal of human genetics
The mean and standard deviation of the first arrival time for a single mutant to reach a certain frequency and the mean age of a mutant persisting in a population have been studied using diffusion methods. These quantities are shown to be highly dependent on both the heterozygous effect and the population size. For partially recessive deleterious mutations, both the mean first arrival time and the mean age decrease with increasing selection coefficient against heterozygotes. For overdominant… CONTINUE READING

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