The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.

@article{Kim1999TheFA,
  title={The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.},
  author={Dong-Ho Kim and John J. Rossi},
  journal={RNA},
  year={1999},
  volume={5 7},
  pages={959-71}
}
The yeast PRP44 gene, alternatively named as BRR2, SLT22, RSS1, or SNU246, encodes a 246-kDa protein with putative RNA helicase function during pre-mRNA splicing. The protein is a typical DEAD/H family member, but unlike most other members of this family, it contains two putative RNA helicase domains, each with a highly conserved ATPase motif. Prior to this study little was known about functional roles for these two domains. We present genetic and biochemical evidence that ATPase motifs of only… CONTINUE READING

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