The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA

@inproceedings{Suwannalai2011TheFS,
  title={The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA},
  author={Parawee Suwannalai and Annemiek Willemze and Linda van Toorn and Gerrie Stoeken-Rijsbergen and Nivine E W Levarht and Jan Wouter Drijfhout and Tom W J Huizinga and Rene E M Toes and Leendert A Trouw},
  booktitle={Arthritis research & therapy},
  year={2011}
}
INTRODUCTION The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T-cell-dependent protein antigens typically produce IgG and not IgM antibodies. In this study, we analyzed whether a difference exists between the fine specificity of IgM versus IgG anti-citrullinated protein antibodies (ACPAs). METHODS We determined… CONTINUE READING