The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?

@article{Henquin1992TheFA,
  title={The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?},
  author={J. -C. Henquin},
  journal={Diabetologia},
  year={1992},
  volume={35},
  pages={907-912}
}
Probably over 20 million patients world-wide suffering from Type 2 (non-insulin-dependent) diabetes mellitus are treated with hypoglycaemic sulphonylureas. In fact, all antidiabetic drugs currently used with the aim of stimulating insulin release belong to this family. Soon after the discovery of insulin, Abel and Geiling [1] showed that the hormone contains large amounts of sulphur which is essential for its biological action. These observations prompted several studies on the possible effects… CONTINUE READING

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